By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Sign In
Time puterTime puter
Aa
  • Home
  • Social Media
  • Softwares
  • Gadgets
  • Mobiles
  • Solution
  • Apple
  • News
  • Contact Us!
Reading: Hair thinning by stem cell loss
Share
Time puterTime puter
Aa
Search
  • Home
  • Social Media
  • Softwares
  • Gadgets
  • Mobiles
  • Solution
  • Apple
  • News
  • Contact Us!
Have an existing account? Sign In
Follow US
© 2022 Foxiz News Network. Ruby Design Company. All Rights Reserved.
Time puter > News > Hair thinning by stem cell loss
News

Hair thinning by stem cell loss

Deep
Last updated: 2016/03/17 at 12:09 PM
Deep Published March 17, 2016
Share
2 Min Read

Why people lose their locks in old age may be related to the aging of hair follicle stem cells, two new studies suggest. Though it is known that mammals that live for longer lifespans lose their hair, the mechanisms underlying this fate have been a mystery. Hair follicle stem cells (HFSCs), which generate the sacs or follicles that produce hair, keep hair growth going repeatedly over time.

Surprisingly, they have even been shown, in mice experiments, to resist aging. To better understand the role HFSCs might play in aging-associated hair loss, Hiroyuki Matsumura and colleagues studied hair follicles in a mouse model of accelerated hair loss. An analysis of the animals’ skin at 18 months, a stage when their hair loss begins, showed that their hair follicles were miniaturized and reduced in number and thickness.

The researchers hypothesized that changes in follicle-generating HFSCs might be to blame, and further studies — including of key genes involved in HFSC maintenance -confirmed their hypothesis. Accumulating DNA damage in the hair follicle stem cells seems to play a role in driving the changes to them, the authors say.

One gene found to be especially important to regulating HFSCs was COL17A1; HFSCs are eliminated in mice engineered to lack this factor. A second study identifies a transcription factor that HFSCs use to initiate hair growth. During the adult hair cycle, HFSCs periodically go through phases of activation and quiescence to maintain a stem cell population and to produce new hair follicles. By manipulating expression of Foxc1 at different stages of the hair growth cycle, Li Wang et al. determined that this transcription factor promotes signaling between two key mechanisms that control quiescence, Nfatc1 and BMP. These findings suggest that quiescent HFSCs sense the change of their cellular states and utilize transient gene activation to maintain their identity.

Together, these two studies add volume to the research surrounding hair growth.
[“source -pcworld”]

TAGGED: by, cell, Hair, loss, stem, thinning

Sign Up For Daily Newsletter

Be keep up! Get the latest breaking news delivered straight to your inbox.
[mc4wp_form]
By signing up, you agree to our Terms of Use and acknowledge the data practices in our Privacy Policy. You may unsubscribe at any time.
Deep March 17, 2016
Share
Previous Article Basic Concept: Hair Transplantation
Next Article US says cyber battle against ISIS will ‘black these guys out’

Recent Post

  • The Consequences of Ignoring Pregnancy Cravings: Potential Risks and Challenges
  • Navigating Pregnancy After Abdominoplasty: Considerations and Precautions
  • Managing Itchy Breasts During Pregnancy: Causes and Solutions
  • Understanding Eye Twitching During Pregnancy
  • Blessed with a Bundle of Joy: Our Family is Growing!
  • Surprising Dad on Father’s Day with the Best Gift Ever: A New Baby!
  • The Benefits of Using Spider Tape for Pregnancy Support and Comfort
  • Cakes to announce pregnancy: Baby on the Way and a Cake to Match!
Join Us!

Subscribe to our newsletter and never miss our latest news, podcasts etc..

[mc4wp_form]
Zero spam, Unsubscribe at any time.

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?